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LEC.433: Safety and environmental impact assessment: an industrial perspective

Department: Lancaster Environment Centre NCF Level: FHEQ/QCF/NQF7//RQF7
Study Level: Postgraduate (Masters level) Credit Points: 15.0
Start Date: 12-01-2015 End Date: 13-02-2015
Available for Online Enrolment?: Y Enrolment Restriction: Fully available to all students
Module Convenor: Professor FL Martin

Syllabus Rules and Pre-requisites

Curriculum Design: Outline Syllabus

  • Lectures:

    1-2. Introduction to Toxicity Testing in the 21st Century (TT21C)

    3-4. Chemical MIE

    5-6. Biodynamics

    7-8. Biokinetics /QIVIVE

    9-10. Case studies / Terminus


    1. TT21C/AOP

    2. Chemical MIE

    3. Biodynamics

    4. Biokinetics /QIVIVE

    5. Case studies / Terminus



Curriculum Design: Pre-requisites/Co-requisites/Exclusions

  • None

Curriculum Design: Single, Combined or Consortial Schemes to which the Module Contributes

  • An optional module on the following schemes:

    MSc Environmental & Biochemical Toxicology

    MSc Contamination, Risk Assessment & Remediation

    MSc Environmental Science & Technology

    MSc (Research) International Master's Environmental Science & Technology


  • 25% Coursework
  • 75% Essay(s)

Assessment: Details of Assessment

  • 100% coursework

    Overview of TT21C vision and how it’s been received by the scientific community e.g., ToxCast screening vs. focused pathway approaches for safety assessment. Would require 200 words and minimum 15 references.


Educational Aims: Subject Specific: Knowledge, Understanding and Skills

  • This module covers the link between science and industry in relation to chemical safety and environmental impact risk assessments. Companies, such as Unilever, have taken a lead in developing state-of-the-art biological approaches to enable us to make decisions regarding the risk from chemical exposures in the environment. This is a paradigm shift away from traditional risk assessment strategies. Uniquely, this course will be delivered exclusively by individuals from industry who have pioneered these developments internationally. This is a major opportunity to witness how laboratory-based academic research translates into end-user, industrial applications.

Educational Aims: General: Knowledge, Understanding and Skills

  • Through first-hand access to leading personnel from Industry, lectures and workshops the module will introduce and emphasise to students the necessity to translate laboratory-based academic developments to an end-user stage. It will also familiarise the students with the importance of cross-talk between different disciplines in order to arrive at an appropriate modern assessment of adverse effects. Many traditional techniques (such as animal testing) are no longer applicable, so novel systems biology approaches are need to extrapolate from the laboratory to the real-world. The students will develop skills needed to discuss findings in different areas and understand how these may complement each other. There'll be contact with and knowledge of a broad range of problems and stakeholders to increase the students' ability to assess evidence from very different sources to allow them to critically evaluate in a modern context chemical safety and environmental impacts.

Learning Outcomes: Subject Specific: Knowledge, Understanding and Skills

  • On successful completion of this module students will be able to...

    •  Understand how new science thinking will influence assessments of chemical safety and environmental impact
    • Critically evaluate information from different areas such as in silico to bioinformatics in order to evaluate risk of an adverse effect
    • Understand the context of the "Adverse Outcome Pathway (AOP)" programe for environmental toxicity assessments
    • Consider the accuracy and cost-effectiveness of extrapolating laboratory-based findings to real-world scenarios - what is the "weight of evidence" underpinning a decsion regarding chemical safety
    • Consider how cross-talk between independent discipline can allow for informed decisions against the backdrop of a complex systems biology approach
    • Understand synergies and tradeoffs in the pursuit of risk assessment of chemicals and environmental impacts
    • Analyze complex sources of evidence from differing fields and identify how they complement each other towards arriving at an informed decision regarding risk assessment
    • Evaluate the challenges of implementing such strategies to satisfy regulators internationally
    • Understand the industry perspective - how can this systems approach work towards safe chemicals management
    • Evaluate the removal of traditional apical endpoints of toxicological assessment and bring novel science thinking to decisions governing the safe use of chemicals

Learning Outcomes: General: Knowledge, Understanding and Skills

  • On successful completion of this module students will be able to...

    • Develop critical arguments based on evidence from a modern systems biology approach
    • Write and discuss effectively using a diverse evidence base
    • Critically evaluate National and International policies in risk assessment and environmental impact
    • Implement strategies to allow for integration of laboratory-based findings from diverse sources into a unified decision-making policy
    • Demonstrate original thinking
    • Contribute to Workshops and interact with visiting Industry personnel with confident and thoughful discussion

Contact Information

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